Natasha joined the Genome Plasticity and Disease group in January 2021 to study the mechanisms governing expression from proviral DNA. Natasha has a background in molecular epigenetics. She was awarded her PhD in the lab of Professor Marnie Blewitt, at WEHI in Melbourne, Australia in 2018. There, she characterised the structural maintenance of chromosomes protein, Smchd1, in mammalian development. Natasha was awarded a Humboldt Research Fellowship, HFSP Postdoctoral Fellowship, and an EMBO Postdoctoral Fellowship (non-stipendiary) to train at the Institute of Epigenetics and Stem Cells in Munich, Germany, where she studied transposable element function in preimplantation development. Natasha has joined the team of Professor Geoffrey Faulkner, supported by an NHMRC Investigator Grant, to investigate mechanisms underlying endogenous and exogenous retrovirus regulation in infectious and malignant disease.

Research Links:

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Jansz, Natasha; Faulkner, Geoffrey J

Endogenous retroviruses in the origins and treatment of cancer (Journal Article)

In: Genome Biology, 22 (1), pp. 147, 2021, ISSN: 1474-760X.

(Abstract | Links | BibTeX | Altmetric)


Jansz, Natasha; Torres-Padilla, Maria-Elena

Genome activation and architecture in the early mammalian embryo (Journal Article)

In: Current Opinion in Genetics & Development, 55 , pp. 52–58, 2019, ISSN: 0959-437X.

(Abstract | Links | BibTeX | Altmetric)

Delbridge, Alex R D; Kueh, Andrew J; Ke, Francine; Zamudio, Natasha M; El-Saafin, Farrah; Jansz, Natasha; Wang, Gao-Yuan; Iminitoff, Megan; Beck, Tamara; Haupt, Sue; Hu, Yifang; May, Rose E; Whitehead, Lachlan; Tai, Lin; Chiang, William; Herold, Marco J; Haupt, Ygal; Smyth, Gordon K; Thomas, Tim; Blewitt, Marnie E; Strasser, Andreas; Voss, Anne K

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects (Journal Article)

In: Cell Reports, 27 (2), pp. 442–454.e5, 2019, ISSN: 2211-1247.

(Abstract | Links | BibTeX | Altmetric)

Jansz, Natasha

DNA methylation dynamics at transposable elements in mammals (Journal Article)

In: Essays in Biochemistry, 63 (6), pp. 677–689, 2019, ISSN: 0071-1365.

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Jansz, Natasha; Nesterova, Tatyana; Keniry, Andrew; Iminitoff, Megan; Hickey, Peter F; Pintacuda, Greta; Masui, Osamu; Kobelke, Simon; Geoghegan, Niall; Breslin, Kelsey A; Willson, Tracy A; Rogers, Kelly; Kay, Graham F; Fox, Archa H; Koseki, Haruhiko; Brockdorff, Neil; Murphy, James M; Blewitt, Marnie E

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway (Journal Article)

In: Cell Reports, 25 (7), pp. 1912–1923.e9, 2018, ISSN: 2211-1247.

(Abstract | Links | BibTeX | Altmetric)

Jansz, Natasha; Keniry, Andrew; Trussart, Marie; Bildsoe, Heidi; Beck, Tamara; Tonks, Ian D; Mould, Arne W; Hickey, Peter; Breslin, Kelsey; Iminitoff, Megan; Ritchie, Matthew E; McGlinn, Edwina; Kay, Graham F; Murphy, James M; Blewitt, Marnie E

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters (Journal Article)

In: Nature Structural & Molecular Biology, 25 (9), pp. 766–777, 2018, ISSN: 1545-9985, (Bandiera_abtest: a Cg_type: Nature Research Journals Number: 9 Primary_atype: Research Publisher: Nature Publishing Group Subject_term: Chromatin structure;Dosage compensation;Epigenomics;Gene silencing Subject_term_id: chromatin-structure;dosage-compensation;epigenomics;gene-silencing).

(Abstract | Links | BibTeX | Altmetric)


Liu, Xiaodong; Nefzger, Christian M; Rossello, Fernando J; Chen, Joseph; Knaupp, Anja S; Firas, Jaber; Ford, Ethan; Pflueger, Jahnvi; Paynter, Jacob M; Chy, Hun S; O'Brien, Carmel M; Huang, Cheng; Mishra, Ketan; Hodgson-Garms, Margeaux; Jansz, Natasha; Williams, Sarah M; Blewitt, Marnie E; Nilsson, Susan K; Schittenhelm, Ralf B; Laslett, Andrew L; Lister, Ryan; Polo, Jose M

Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming (Journal Article)

In: Nature Methods, 14 (11), pp. 1055–1062, 2017, ISSN: 1548-7105, (Bandiera_abtest: a Cg_type: Nature Research Journals Number: 11 Primary_atype: Research Publisher: Nature Publishing Group Subject_term: Biological models;Embryonic stem cells;Pluripotent stem cells;Reprogramming Subject_term_id: biological-models;embryonic-stem-cells;pluripotent-stem-cells;reprogramming).

(Abstract | Links | BibTeX | Altmetric)

Jansz, Natasha; Chen, Kelan; Murphy, James M; Blewitt, Marnie E

The Epigenetic Regulator SMCHD1 in Development and Disease (Journal Article)

In: Trends in Genetics, 33 (4), pp. 233–243, 2017, ISSN: 0168-9525.

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Keniry, Andrew; Gearing, Linden J; Jansz, Natasha; Liu, Joy; Holik, Aliaksei Z; Hickey, Peter F; Kinkel, Sarah A; Moore, Darcy L; Breslin, Kelsey; Chen, Kelan; Liu, Ruijie; Phillips, Catherine; Pakusch, Miha; Biben, Christine; Sheridan, Julie M; Kile, Benjamin T; Carmichael, Catherine; Ritchie, Matthew E; Hilton, Douglas J; Blewitt, Marnie E

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing (Journal Article)

In: Epigenetics & Chromatin, 9 (1), pp. 16, 2016, ISSN: 1756-8935.

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Liu, Ruijie; Chen, Kelan; Jansz, Natasha; Blewitt, Marnie E; Ritchie, Matthew E

Transcriptional profiling of the epigenetic regulator Smchd1 (Journal Article)

In: Genomics Data, 7 , pp. 144–147, 2016, ISSN: 2213-5960.

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Liu, Ruijie; Holik, Aliaksei Z; Su, Shian; Jansz, Natasha; Chen, Kelan; Leong, Huei San; Blewitt, Marnie E; Asselin-Labat, Marie-Liesse; Smyth, Gordon K; Ritchie, Matthew E

Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses (Journal Article)

In: Nucleic Acids Research, 43 (15), pp. e97–e97, 2015, ISSN: 0305-1048.

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