Dr. Santiago Morell obtained his bachelor degree in Biology in 2007 in the University of Granada (Spain), and then started his scientific career in 2008 as a research assistant in the Andalusian Stem Cell Bank (Granada, Spain). Soon afterwards, driven by his interest in the relationship between mobile elements and genetic disease in humans, he joined Dr. Jose Luis Garcia-Perez lab in the Andalusian Stem Cell Bank as a PhD student and Research assistant, and his studies in LINE-1 (L1) and DNA repair awarded him his Research Proficiency in Genetics and Evolution in 2010.In 2010-2011 he was invited to do a short term stay in John V. Moran’s lab, in the department of Human Genetics in the University of Michigan Medical School, in Ann Arbor (Michigan, USA), where he continued his work in the relationship between L1 and DNA repair machinery. Afterwards, he returned to Dr Garcia-Perez’s new lab in the Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENYO), in Granada, to continue these studies, leading to the award of his PhD in Biomedicine in late 2014.
In 2013 Dr. Morell joined Prof. Faulkner’s lab in the Mater Research Institute, University of Queensland, in Brisbane, QLD (Australia) to continue his research in the relationship between mobile elements and human genetic diseases, but now with a new perspective from the neuroscience field, with the exciting task of revisiting the role of the deregulated LINE-1 activity in Rett Syndrome, being this work a part of an ongoing collaborative effort to discern the impact of retrotransposons in abnormal brain development and mental diseases.
Dr. Morell has worked in three of the best laboratories of the LINE-1 field (Dr. Jose L. Garcia-Perez, Dr. John V. Moran and Prof. Geoffrey J. Faulkner labs), making him experienced in different Molecular Biology and Tissue Culture techniques, including cloning, L1 and Alu retrotransposition assays and recovery and characterization of L1 insertions.
Dr. Morell is passionate about biomedical research and aims to be a part in the transition from the exciting findings taking place in the L1 field and the application of innovative treatments for patients in the future.
In: Mob. DNA, 7 (1), pp. 21, 2016.
L1 retrotransposons and somatic mosaicism in the brain (Journal Article)
In: Annu. Rev. Genet., 48 , pp. 1–27, 2014.
- Cano D, Morell S, Pulgarin AJ, Amador S, Garcia-Pérez JL. Characterization of Engineered L1 Retrotransposition Events: The Recovery Method. Methods Mol Biol (2016)
- Munoz-Lopez M, Garcia-Canadas M, Macia A, Morell S, Garcia-PerezJL. Analysis of LINE-1 expression in human pluripotent cells. Methods Mol Biol (2012)
- Macia A, Munoz-Lopez M, Cortez JL, Hastings RK, Morell S, Lucena-Aguilar G, Marchal JA, Badge RM, Garcia-Perez JL. Epigenetic control of retrotransposon expression in human embryonic stem cells. Mol Cell Biol (2011)
- Garcia-Perez JL, Morell M, Scheys JO, Kulpa DA, Morell S, Carter CC, Hammer GD, Collins KL, O’Shea KS, Menendez P, Moran JV. Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature (2010)