Jay RasmussenJay has had the opportunity to investigate different aspects of brain dysfunction in a variety of labs around the world. He first gained experience with neurodevelopment and neurodegeneration research during his BSc and MSc at the University of Alberta in Edmonton, Canada. Specifically, his research on prion diseases sparked his interest in neurodegeneration and the mechanisms behind brain deterioration. This led to the pursuit of a PhD in Tübingen, Germany in the lab of Professor Mathias Jucker starting in mid-2014 (Hertie Institute for Clinical Brain Research-HIH and the German Center for Neurodegenerative Diseases-DZNE). Here, Jay focused on the biochemical features of pathological protein deposits called senile plaques that are associated with Alzheimer’s disease and are made up of β-amyloid protein. This lead to the discovery that different subtypes of Alzheimer’s disease have distinct plaque features and that the earliest forms of deposited β-amyloid protein are uniquely influential in initiating a disease cascade.

 From the results of his PhD, Jay was intrigued at the heterogeneity in disease onset and the diversity of symptoms in patients suffering from neurodegenerative diseases like Alzheimer’s disease. The concept of genomic/cellular mosaicism jumped out as a currently unclear influence on how neurodegenerative diseases develop differently in the brains of an increasingly large population of patients. Jay joined the lab of Professor Geoffrey Faulkner in early 2018 to pursue this link between mosaicism and neurodegeneration in age-related diseases like Alzheimer’s disease.

Research Links:

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Rasmussen, Jay; Krasemann, Susanne; Altmeppen, Hermann; Schwarz, Petra; Schelle, Juliane; Aguzzi, Adriano; Glatzel, Markus; Jucker, Mathias

Infectious prions do not induce Aβ deposition in an in vivo seeding model (Journal Article)

Acta Neuropathol, 135 (6), pp. 965–967, 2018, ISSN: 0001-6322, 1432-0533.

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Klima, Cassidy L; Zaheer, Rahat; Cook, Shaun R; Rasmussen, Jay; Alexander, Trevor W; Potter, Andrew; Hendrick, Steve; McAllister, Tim A

In silico identification and high throughput screening of antigenic proteins as candidates for a Mannheimia haemolytica vaccine (Journal Article)

Veterinary Immunology and Immunopathology, 195 , pp. 19–24, 2018, ISSN: 01652427.

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Rasmussen, Jay; Jucker, Mathias; Walker, Lary C

Aβ seeds and prions: How close the fit? (Journal Article)

Prion, 11 (4), pp. 215–225, 2017, ISSN: 1933-6896, 1933-690X.

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Rasmussen, Jay; Mahler, Jasmin; Beschorner, Natalie; Kaeser, Stephan A; Häsler, Lisa M; Baumann, Frank; Nyström, Sofie; Portelius, Erik; Blennow, Kaj; Lashley, Tammaryn; Fox, Nick C; Sepulveda-Falla, Diego; Glatzel, Markus; Oblak, Adrian L; Ghetti, Bernardino; Nilsson, Peter K R; Hammarström, Per; Staufenbiel, Matthias; Walker, Lary C; Jucker, Mathias

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease (Journal Article)

Proc Natl Acad Sci USA, 114 (49), pp. 13018–13023, 2017, ISSN: 0027-8424, 1091-6490.

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Ye, Lan; Rasmussen, Jay; Kaeser, Stephan A; Marzesco, Anne‐Marie; Obermüller, Ulrike; Mahler, Jasmin; Schelle, Juliane; Odenthal, Jörg; Krüger, Christian; Fritschi, Sarah K; Walker, Lary C; Staufenbiel, Matthias; Baumann, Frank; Jucker, Mathias

Aβ seeding potency peaks in the early stages of cerebral β‐amyloidosis (Journal Article)

EMBO Rep., 18 (9), pp. 1536–1544, 2017, ISSN: 1469-221X, 1469-3178, 1469-221X, 1469-3178.

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Klima, Cassidy L; Cook, Shaun R; Zaheer, Rahat; Laing, Chad; Gannon, Vick P; Xu, Yong; Rasmussen, Jay; Potter, Andrew; Hendrick, Steve; Alexander, Trevor W; McAllister, Tim A

Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources (Journal Article)

PLoS ONE, 11 (2), pp. e0149520, 2016, ISSN: 1932-6203.

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Rasmussen, Jay; Gilroyed, Brandon H; Reuter, Tim; Badea, Ana; Eudes, François; Graf, Robert; Laroche, André; Kav, Nat N V; McAllister, Tim A

Protein can be taken up by damaged wheat roots and transported to the stem (Journal Article)

J. Plant Biol., 58 (1), pp. 1–7, 2015, ISSN: 1226-9239, 1867-0725.

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Xu, Shanwei; Rasmussen, Jay; Ding, Ning; Neumann, Norman F; El-Din, Mohamed Gamal; Belosevic, Miodrag; McAllister, Tim

Inactivation of infectious prions in the environment: a mini-review (Journal Article)

Journal of Environmental Engineering and Science, 9 (2), pp. 125–136, 2014, ISSN: 1496-2551, 1496-256X.

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Rasmussen, Jay; Gilroyed, Brandon H; Reuter, Tim; Dudas, Sandor; Neumann, Norman F; Balachandran, Aru; Kav, Nat NV; Graham, Catherine; Czub, Stefanie; McAllister, Tim A

Can plants serve as a vector for prions causing chronic wasting disease? (Journal Article)

Prion, 8 (1), pp. 136–142, 2014, ISSN: 1933-6896, 1933-690X.

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Rasmussen, Jay; Gilroyed, Brandon H; Reuter, Tim; Badea, Ana; Eudes, François; Graf, Robert; Laroche, André; Kav, Nat N V; McAllister, Tim A

Efficiency of protein as a nitrogen source for wheat and morphological changes in roots exposed to high protein concentrations (Journal Article)

Can. J. Plant Sci., 94 (4), pp. 603–613, 2014, ISSN: 0008-4220, 1918-1833.

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Campeau, Jody L; Wu, Gengshu; Bell, John R; Rasmussen, Jay; Sim, Valerie L

Early Increase and Late Decrease of Purkinje Cell Dendritic Spine Density in Prion-Infected Organotypic Mouse Cerebellar Cultures (Journal Article)

PLoS ONE, 8 (12), pp. e81776, 2013, ISSN: 1932-6203.

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Kooistra, Megan K; Leduc, Renee Y M; Dawe, Christine E; Fairbridge, Nicholas A; Rasmussen, Jay; Man, Julie H Y; Bujold, Mattea; Juriloff, Diana; King-Jones, Kirst; McDermid, Heather E

Strain-specific modifier genes of textitCecr2 -associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes (Journal Article)

Physiological Genomics, 44 (1), pp. 35–46, 2012, ISSN: 1094-8341, 1531-2267.

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